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Pristiq (Desvenlafaxine) Extended-Release Tablets

Antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions

Read the Medication Guide that comes with your or your family member's antidepressant medicine. This Medication Guide is only about the risk of suicidal thoughts and actions with antidepressant medicines.

Talk to your, or your family member's, healthcare provider about:
  • all risks and benefits of treatment with antidepressant medicines
  • all treatment choices for depression or other serious mental illness

    What is the most important information I should know about antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions?

    1. Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment.
    2. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Some people may have a particularly high risk of having suicidal thoughts or actions. These include people who have (or have a family history of) bipolar illness (also called manic-depressive illness) or suicidal thoughts or actions.
    3. How can I watch for and try to prevent suicidal thoughts and actions in myself or a family member?
  • Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.
  • Call the healthcare provider right away to report new or sudden changes in mood, behavior, thoughts, or feelings.
  • Keep all follow-up visits with the healthcare provider as scheduled. Call the healthcare provider between visits as needed, especially if you have concerns about symptoms.

    Call a healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you:
  • thoughts about suicide or dying
  • trouble sleeping (insomnia)
  • attempts to commit suicide
  • new or worse irritability
  • new or worse depression
  • acting aggressive, being angry, or violent
  • new or worse anxiety
  • acting on dangerous impulses
  • an extreme increase in activity and talking
  • feeling very agitated or restless (mania)
  • panic attacks
  • other unusual changes in behavior or mood

    What else do I need to know about antidepressant medicines?

  • Never stop an antidepressant medicine without first talking to a healthcare provider. Stopping an antidepressant medicine suddenly can cause other symptoms.
  • Antidepressants are medicines used to treat depression and other illnesses. It is important to discuss all the risks of treating depression and also the risks of not treating it. Patients and their families or other caregivers should discuss all treatment choices with the healthcare provider, not just the use of antidepressants.
  • Antidepressant medicines have other side effects. Talk to the healthcare provider about the side effects of the medicine prescribed for you or your family member.
  • Antidepressant medicines can interact with other medicines. Know all of the medicines that you or your family member takes. Keep a list of all medicines to show the healthcare provider. Do not start new medicines without first checking with your healthcare provider.
  • Not all antidepressant medicines prescribed for children are FDA approved for use in children. Talk to your child's healthcare provider for more information.

    This Medication Guide has been approved by the U.S. Food and Drug Administration for all antidepressants.

    Important information about Pristiq (Desvenlafaxine Succinate) extended-release tablets

    Read the patient information that comes with Pristiq before you take this medication and each time you refill your prescription. There may be new information. If you have questions, ask your healthcare provider. This information does not take the place of talking with your healthcare provider about your medical condition or treatment.

    What is Pristiq?

  • Pristiq is a prescription medicine used to treat depression. This drug belongs to a class of medicines known as SNRIs (or serotonin-norepinephrine reuptake inhibitors).
  • Pristiq (Desvenlafaxine) has not been studied or approved for use in children and adolescents.

    Who should not take Pristiq?

    Do not take PRISTIQ if you:
  • are allergic to desvenlafaxine, venlafaxine or any of the ingredients in Pristiq (Desvenlafaxine Succinate). See the end of this Medication Guide for a complete list of ingredients in this medicine.
  • currently take or have taken within the last 14 days, any medicine known as an MAOI. Taking an MAOI with certain other medicines, including Pristiq (Desvenlafaxine), can cause serious or even life-threatening side effects. Also, you must wait at least 7 days after you stop taking this medication before you take any MAOI.

    What should I tell my healthcare provider before taking Pristiq (Desvenlafaxine)?

    Tell your healthcare provider about all your medical conditions, including if you:
  • have high blood pressure
  • have high cholesterol or high triglycerides
  • have heart problems
  • have a history of a stroke
  • have glaucoma
  • have kidney problems
  • have or had depression, suicidal thoughts or behavior
  • have liver problems
  • have or had seizures or convulsions
  • have mania or bipolar disorder
  • have or had bleeding problems
  • have low sodium levels in your blood
  • are pregnant or plan to become pregnant. It is not known if Pristiq will harm your unborn baby.
  • are breastfeeding. This drug can pass into your breast milk and may harm your baby. Talk with your healthcare provider about the best way to feed your baby if you take Pristiq (Desvenlafaxine Succinate).

    Serotonin syndrome or neuroleptic malignant syndrome (NMS)-like reactions

    Rare, but potentially life-threatening, conditions called serotonin syndrome or Neuroleptic Malignant Syndrome (NMS)-like reactions can happen when medicines such as Pristiq are taken with certain other medicines. Serotonin syndrome or NMS-like reactions can cause serious changes in how your brain, muscles, heart and blood vessels, and digestive system work. Especially tell your healthcare provider if you take the following:
  • medicines to treat migraine headaches known as triptans
  • medicines used to treat mood, anxiety, psychotic, or thought disorders, including tricyclics, lithium, selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), antipsychotic drugs, or other dopamine antagonists, such as metoclopramide
  • tramadol
  • silbutramine
  • St. John's Wort
  • tryptophan supplements
  • MAOIs (including linezolid, an antibiotic)

    Ask your doctor or pharmacist if you are not sure if you are taking any of these medicines.

    Before you take Pristiq (Desvenlafaxine) with any of these medicines, talk to your healthcare provider about serotonin syndrome.

    Pristiq contains the medicine desvenlafaxine. Do not take this medication with other medicines containing venlafaxine or desvenlafaxine.

    How should I take Pristiq?

  • Take this medication exactly as your healthcare provider has told you.
  • Take Desvenlafaxine (Pristiq) at about the same time each day.
  • Pristiq may be taken either with or without food.
  • Swallow this drug tablets whole, with fluid. Do not crush, cut, chew, or dissolve Pristiq tablets because the tablets are time-released.
  • When you take Pristiq (Desvenlafaxine Succinate), you may see something in your stool that looks like a tablet. This is the empty shell from the tablet after the medicine has been absorbed by your body.
  • It is common for antidepressant medicines such as Pristiq to take several weeks before you start to feel better. Do not stop taking this medicine if you do not feel results right away.
  • Do not stop taking or change the dose of Pristiq (Desvenlafaxine) without talking with your healthcare provider, even if you feel better.
  • Talk with your healthcare provider about how long you should use this medication. Take Pristiq for as long as your healthcare provider tells you to.
  • If you miss a dose of Pristiq (Desvenlafaxine Succinate), take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not try to "make up" for the missed dose by taking two doses at the same time.
  • Do not take more Pristiq (Desvenlafaxine) than prescribed by your healthcare provider. If you take more this drug than the amount prescribed, contact your healthcare provider right away.
  • In case of an overdose of Desvenlafaxine (Pristiq), call your healthcare provider or poison control center, or go to the emergency room right away.

    Switching from other antidepressants

    Side effects from discontinuing antidepressant medication have occurred when patients switched from other antidepressants, including venlafaxine, to Pristiq (Desvenlafaxine). Your doctor may gradually reduce the dose of your initial antidepressant medication to help to reduce these side effects.

    What should I avoid while taking Pristiq?

  • Do not drive a car or operate machinery until you know how Desvenlafaxine (Pristiq) affects you.
  • Avoid drinking alcohol while taking this medicine.

    What are the possible side effects of Pristiq?

    Desvenlafaxine (Pristiq) can cause serious side effects, including:
  • See the beginning of this Medication Guide - Antidepressant Medicines, Depression and other Serious Mental Illnesses, and Suicidal Thoughts or Actions.
  • Serotonin syndrome or neuroleptic malignant syndrome (NMS)-like reactions.

    Get medical help right away if you think that you have these syndromes. Signs and symptoms of these syndromes may include one or more of the following:

    - restlessness
    - hallucinations (seeing and hearing things that are not real)
    - increase in blood pressure
    - diarrhea
    - coma
    - loss of coordination
    - fast heart beat
    - increased body temperature
    - nausea
    - vomiting
    - confusion
    - muscle stiffness

    Pristiq (Desvenlafaxine) may also cause other serious side effects, including:

  • New or worsened high blood pressure (hypertension). Your healthcare provider should monitor your blood pressure before and while you are taking this medicine. If you have high blood pressure, it should be controlled before you start taking Pristiq.
  • Abnormal bleeding or bruising. This medication and other SNRIs/SSRIs may cause you to have an increased chance of bleeding. Taking aspirin, NSAIDs (non-steroidal antiinflammatory drugs), or blood thinners may add to this risk. Tell your healthcare provider right away about any unusual bleeding or bruising.
  • Glaucoma (increased eye pressure)
  • Increased cholesterol and triglyceride levels in your blood
  • Symptoms when stopping Pristiq (discontinuation symptoms). Side effects may occur when stopping this drug (discontinuation symptoms), especially when therapy is stopped suddenly. Your healthcare provider may want to decrease your dose slowly to help avoid side effects. Some of these side effects may include:
    - dizziness
    - nausea
    - anxiety
    - abnormal dreams
    - tiredness
    - headache
    - irritability
    - sleeping problems (insomnia)
    - sweating
    - diarrhea

  • Seizures (convulsions)
  • Low sodium levels in your blood. Symptoms of this may include: difficulty concentrating, headache, memory changes, confusion, weakness and unsteadiness on your feet. In severe or more sudden cases, symptoms can include: hallucinations (seeing or hearing things that are not real), seizures, fainting, coma. If not treated, severe low sodium levels could be fatal.
  • Allergic reactions. Some reactions can be severe such as swelling beneath the skin (e.g., throat, face, hands).

    Contact your healthcare provider if you think you have any of these side effects.

    Common side effects with Pristiq (Desvenlafaxine Succinate) include:
  • nausea
  • headache
  • tiredness
  • diarrhea
  • vomiting
  • dry mouth
  • sweating
  • dizziness
  • anxiety
  • tremor
  • dilated pupils
  • insomnia
  • decreased sex drive
  • constipation
  • loss of appetite
  • sleepiness
  • delayed orgasm and ejaculation
  • feeling that your surroundings are spinning or moving

    These are not all the possible side effects of Desvenlafaxine (Pristiq). Tell your healthcare provider about any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects. You may report side effects to FDA. For more information on these and other side effects associated with this medicine, talk to your healthcare provider.

    How should I store Pristiq (Desvenlafaxine)?

  • Store Pristiq at 68° to 77°F (20° to 25°C).
  • Do not use this medication after the expiration date (EXP), which is on the container. The expiration date refers to the last day of that month.
  • Keep Desvenlafaxine Succinate (Pristiq) and all medicines out of the reach of children.

    General Information about the safe and effective use of Pristiq

    Medicines are sometimes used for conditions that are not mentioned in Medication Guides. Do not use Pristiq (Desvenlafaxine) for a condition for which it was not prescribed. Do not give this drug to other people, even if they have the same symptoms that you have. It may harm them.

    This Medication Guide summarizes the most important information about Pristiq. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about this medicine that is written for healthcare professionals.

    What are the ingredients in Pristiq?

    Active ingredient: desvenlafaxine

    Inactive ingredients:

    For the 50 mg tablet, hypromellose, talc, microcrystalline cellulose, magnesium stearate and film coating, which consists of polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, and iron oxides.

    For the 100 mg tablet, hypromellose, microcrystalline cellulose, talc, magnesium stearate, a film coating which consists of polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, iron oxide and FD & C yellow #6.

    This Medication Guide has been approved by the U.S. Food and Drug Administration.

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